- Discussion of the broad categories of mutations (chromosome and gene) - Division of gene mutations into point and indel mutations - Division of point mutations into silent, missense and nonsense mutations (with examples) - Comparisons of the varying effects of the different types of mutations, with indel and nonsense often being the most detrimental - indel mutations cause a FRAME SHIFT in most circumstances meaning that every subsequent triplet is affected by the mutation - Discussion of the need for differential gene expression - this allows cells to become SPECIALISED - they need to express different genes at different times - Discussion of the different types of gene expression control/regulation: 1. Transcriptional 2. Post-transcriptional 3. Post-translational HOMEWORK - revise for mutations quiz, complete the mutations questions sheet and complete the year 12 PLC and bring on a USB
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