Mutations lesson
- Discussion of the broad categories of mutations (chromosome and gene)
- Division of gene mutations into point and indel mutations
- Division of point mutations into silent, missense and nonsense mutations (with examples)
- Comparisons of the varying effects of the different types of mutations, with indel and nonsense often being the most detrimental
- indel mutations cause a FRAME SHIFT in most circumstances meaning that every subsequent triplet is affected by the mutation
- Discussion of the need for differential gene expression - this allows cells to become SPECIALISED - they need to express different genes at different times
- Discussion of the different types of gene expression control/regulation:
1. Transcriptional
2. Post-transcriptional
3. Post-translational
HOMEWORK - revise for mutations quiz, complete the mutations questions sheet and complete the year 12 PLC and bring on a USB
- Division of gene mutations into point and indel mutations
- Division of point mutations into silent, missense and nonsense mutations (with examples)
- Comparisons of the varying effects of the different types of mutations, with indel and nonsense often being the most detrimental
- indel mutations cause a FRAME SHIFT in most circumstances meaning that every subsequent triplet is affected by the mutation
- Discussion of the need for differential gene expression - this allows cells to become SPECIALISED - they need to express different genes at different times
- Discussion of the different types of gene expression control/regulation:
1. Transcriptional
2. Post-transcriptional
3. Post-translational
HOMEWORK - revise for mutations quiz, complete the mutations questions sheet and complete the year 12 PLC and bring on a USB
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